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KMID : 1134820150440121905
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 12 p.1905 ~ p.1911
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Antimelanogenic Effect of Purpurogallin in Murine Melanoma Cells
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Kim Han-Hyuk
Kim Tae-Hoon
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Abstract
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Melanin is one of the most important factors affecting skin color. Melanogenesis is the bioprocess of melanin production by melanocytes in the skin and hair follicles and is mediated by several enzymes, such as tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2. Convenient enzymatic transformation of the simple phenol pyrogallol with polyphenol oxidase originating from pear to an oxidative product, purpurogallin, was efficient. The structure of the pyrogallol oxidation product was identified on the basis of spectroscopic methods. The biotransformation product purpurogallin showed significant inhibitory effects against both melanin synthesis and tyrosinase activity in a dose-dependent manner in B16 melanoma cells. In addition, purpurogallin significantly attenuated melanin production by inhibiting TRP-1, and TRP-2 expression through modulation of their corresponding transcription factors, and microphthalamia-associated transcription factor in B16 cells. Consequently, purpurogallin derived from convenient enzymatic transformation of pyrogallol might be a beneficial material for reducing skin hyperpigmentation.
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KEYWORD
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biotransformation, polyphenol oxidase, antimelanogenesis, oxidation product
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